The Secretory Phospholipase A2 Gene is Required for Gastroesophageal Reflux-Related Changes in Murine Esophagus

Background The initial response of esophageal mucosa to gastroduodenal reflux is inflammation and hyperplasia. Secretory phospholipase A2 (sPLA2) is a known mediator of gut inflammation, and its levels are increased in Barrett’s esophagus. We hypothesized that the sPLA2 gene is required to produce esophageal mucosal hyperplasia in response to gastroduodenal reflux.