Effect of hypomagnesemia on elderly patients with intracerebral hemorrhage

Objective To investigate the effects of hypomagnesemia on the initial amount of hematoma and patient's condition at hospitalization in elderly patients with intracerebral hemorrhage(ICH). The 90 consecutive hospitalized patients with primary ICH were chosen for prospective cohort study in the Second Hospital of Anhui Medical University from February 2017 to May 2018. Methods Demographic and baseline data of patients were collected, and CT scan, serum magnesium concentration and other laboratory examinations after hospital admission were tested.Ninety patients were divided into two groups: hypomagnesemia group(serum magnesium <0.75 mmol/L, n=38)and normo-magnesemia group(0.75-1.25 mmol/L, n=52). The impact of serum magnesium level on the patient's initial volume of hematoma and critical condition at admission were analyzed. Results The median value of random blood glucose(7.29 mmol/L vs.6.44 mmol/L)and fibrinogen degradation products(3.43 mg/L vs.1.98 mg/L)were higher in the patients with hypomagnesemia than in the normal magnesium group.The median volume of initial volume of hematoma at admission was larger in patients with hypomagnesemia than in the normal magnesium group(20 cm3vs.10 cm3). The median value of Glasgow coma scale at admission was lower in patients with hypomagnesemia than in the normal magnesium group(12.5 scores vs.14.0 scores). And their difference was statistically significant(U=-2.663, -2.951, -5.000 and -2.821 respectively, P=0.008, 0.003, 0.000 and 0.005). The correlation analysis showed that the initial volume of hematoma in patients with intracerebral hemorrhage was negatively correlated with the serum magnesium concentration at admission(r=-0.528, P=0.001). Conclusions Patients with hypomagnesemia has a larger hematoma volume and more serious disease condition.There is a significantly negative correlation between serum magnesium and hematoma volume of ICH.The serum magnesium level may become a predictor of ICH in the future. Key words: Cerebral hemorrhage; Magnesium deficiency; Hematoma