Cannabinoid receptor 1 in regulation of lipid metabolism through PPARs pathway

Objective To study the role of cannabinoid receptor 1 (CB1) in the regulation of lipid metabolism through PPARs pathway in diet-induced obese mice. Methods The C57BL/6J male mice were induced with high-fat diet, and then we detected the effect of rimonabant on the body weight, liver weight, and biochemical indicators of the mice. The mRNA levels of CB1, PPARα, PPARβ, and PPARγin subcutaneous fat, visceral fat, skeletal muscle, liver, and heart were detected. Results Rimonabant could decrease the body weight, liver weight, and the mRNA levels of CB1 significantly (allP<0.05). It also ameliorated the serum levels of biochemical indicators (P<0.05). It increased the mRNA levels of PPARαand PPARγin subcutaneous fat, visceral fat, and liver. However, no statistical differences in PPARβwere found in each tissue. Conclusions CB1 plays a role in the regulation of lipid metabolism by controlling PPARαand PPARγ. It provides a reliable theoretical basis for the clinical treatment of lipid metabolism disorders. Key words: Cannabinoid receptor 1; Rimonabant; Peroxisome proliferators activated receptor; Obesity; Lipid metabolism