Breast cancer with synchronous metastases: Impact of locoregional radiotherapy (LRR) on survival

1038 Background: Breast cancer with synchronous metastases is considered as a noncurable disease for which systemic treatment remains the cornerstone of management. However several observational studies have reported a survival benefit for those patients (pts) who were offered a complete excision of the primary tumor. In such setting, locoregional treatment (LRT) may also consist of exclusive locoregional radiotherapy (LRR), as favoured in our institution for the past 2 decades. From our database, we have evaluated the impact of this alternative LRT to surgery on survival of breast cancer pts presenting with synchronous metastases. Methods: Among 18,753 cases diagnosed and treated at Rene Huguenin Cancer Center between 1980 and 2004, 598 pts (3.2%) presented with initial simultaneous distant metastasis. Information regarding demographics, tumor characteristics, site(s) of metastases and treatments were prospectively recorded in the database. The impact of delivery of LRT on overall survival (OS) was evalu...