Regional itching and hyperhidrosis in myeloproliferative disorder with fibrosis: studies on a muscarinic cholinergic receptor M3.

Patients with myeloproliferative disorder (MPD) often develop itching [1]. The pathophysiology of this itching in MPD remains to be fully elucidated. We experienced a patient with MPD, who felt itching only in hyperhidrotic regions, with increased expression of muscarinic cholinergic receptor M3 (CHRM3).A 74-year-old male visited our department due to itching in the face and chest when he sweated. He sweated profusely on the face, chest, and abdomen, while little on the legs. When he sweated on the [...]