Resistance mechanism of imatinib therapy in gastrointestinal stromal tumors

Imatinib,a small-molecule kinase inhibitor,has proven useful in the treatment of recurrent or metastatic gastrointestinal stromal tumors ,However,resistance to imatinib is a more and more serious problem.This review summarizes the existing knowledge of the imatinib resistance mechanism in gastrointestinal stromal tumors and describes the treatment directions in further. Key words: gastrointestinal stromal tumors ;  imatinib;  resistance