Current Approaches and Prospective Drug Targeting to Brain

Abstract The administration of drugs to the CNS has become a difficult task because several barriers in the brain, i.e. the blood-brain barrier (BBB) and a blood-cerebrospinal fluid barrier must be overcome. Several methods to assist in overcoming the BBB have been implemented in recent years, such as osmotic obstruction with the BBB and chemical amplification of prodrugs. Brain targeting creates new doors for scientists to move forward for better investigations so that people with brain diseases can be treated. The current demand is to establish drug delivery techniques to allow the molecules of the drug to efficiently cross the BBB and this study discusses these strategies that efficiently improve the delivery of brain-targeted drugs. Therefore, drugs powered by nanoparticles are being developed via advanced non-invasive methods to control neurological disorders. This study will explore and examine the anatomy and physiology of the BBB, the concept of Magic Bullet, the pathways for drug transport, drug permeability assessment strategies for BBB, and endogenous cells possible interventions as nanoparticles supply cells.