Aarskog-Scott syndrome and atopic dermatitis successfully treated with dupilumab: a casual presentation?

Aarskog-Scott syndrome is a rare genetic X-linked disorder whose prevalence is unknown, but less than 100 cases have been reported in the literature since the first description in 19701 . Aarskog-Scott syndrome is due to a mutation of the FGD1 gene on the X chromosome (Xp11.22). The FGD1 protein plays an important role in signaling within cells and may also be involved in remodeling of the extracellular matrix of blood vessels and cell migration.