Molecular docking study of fucoidan against cyclin-dependent kinase 2 in colorectal carcinoma

Over 9.6 million people have died worldwide accounting to one in six deaths due to cancer. Cancer continues to remain as the second main cause of death in the world. Colorectal cancer (CRC) is the most common cancer globally and its incidence has been increasing continuously over the years. It is the third most general cancer in males and the second in females with over 1.4 million new cancer patients being diagnosed every year. The current study was aimed to screen chemo preventive effect of fucoidan for Colon cancer. Cyclin-dependent kinase 2 was taken as a target protein and it was modelled using I-Tasser. The 3D structure of the compound fucoidan was obtained from PubChem database. The target protein was subjected to perform docking studies with fucoidan. Docking studies were done using Discovery Studio 4.0. From the results, the phytocompound fucoidan from marine weeds showed the best Libdcok score (Libdcok score: 96.7373). Hence, the present study was concluded that the phytocompound fucoidan had potential effect against cyclin-dependent kinase 2 in colorectal carcinoma.