Imidazo (1,2-a) pyridine-2-carboxamides, their preparation and their therapeutic application.

Compounds corresponding to formula (I): wherein: X represents one of the following groups: - a phenyl group optionally substituted with one or more groups selected independently from each other among the following atoms or groups: halogen, (C1-C6) alkyl, (C1-C6), cycloalkyl (C3-C7) alkyl (C1-C6), cycloalkyl (C3-C7) alkoxy (C1-C6) NRaRb, R1 represents a hydrogen atom, a halogen a (C1-C6) alkoxy group, a (C1-C6) alkyl, a (C3-C7) cycloalkyl (C1-C6), cycloalkyl group (C3-C7) alkoxy (C1-C6), an amino, NRcRd group; may be alkyl and alkoxy groups optionally substituted with one or more halogen, hydroxy, amino or alkoxy (C1-C6), R2 represents one of the following groups; - a hydrogen atom, - an alkyl group (C1-C6) optionally substituted with one or more groups selected independently of one another from hydroxy, halogen, hydroxy, amino, NRaRb group, a phenyl group - a (C1-C6) alkoxy group optionally substituted with one or more groups selected independently of one another from hydroxy, halogen, hydroxy, amino, group NRaRb, - a (C3-C7) cycloalkyl (C1-C6), - a (C3-C7) cycloalkyl (C1-C6), - a (C2-C6) alkenyl group, - a (C2-C6) alkynyl group, - a -CO-R5 group - a group -CO-NR6R7 - a -CO-O-R8 group - a group -NR11R12, - - one -NR 9 CO-R10 group a halogen atom, - a cyano group, - a phenyl group optionally substituted with one or more groups chosen independently of each other between atoms or groups: halogen, (C1-C6), NRaRb, -CO-R5, -CO-NR6R7, -CO-O-R8, (C3-C7) alkyl (C1-C6) (C3-C7) alkoxy (C1-C6 ), An alkyl group (C1-C6) optionally substituted with one or more hydroxyl or NRaRb, R3 represents a hydrogen atom, an alkyl group (C1-C6), alkoxy (C1-C6) or a halogen atom, R4 represents a hydrogen atom, an alkyl group (C1-C4), a (C1-C4) alkoxy group or a fluorine atom, R5 represents a hydrogen atom, a phenyl group or an alkyl group (C1-C6), R6 and R7, identical or different, represent a hydrogen atom or an alkyl group (C1-C6) or form with the nitrogen atom a cycle of 4 to 7 members that optionally includes another heteroatom selected from N, O or S, R8 represents an alkyl group (C1-C6), R9 and R10, identical or different, represent a hydrogen atom or an alkyl group (C1-C6) alkyl, R11 and R12, identical or different, represent an alkyl group (C1-C6) or form with the nitrogen atom a cycle of 4 to 7 members that optionally includes another heteroatom selected from N, O or S, Ra and Rb are each independently other, hydrogen, (C1-C6) or form with the nitrogen atom a cycle of 4 to 7 members, Rc is hydrogen and Rd is (C1-C6) and at least one of the substituents R1, R2, R3 and R4 is other than hydrogen; and when R3 is methyl, X is unsubstituted; when R1 is a methyl, X is unsubstituted when R2 is chlorine, X is not a para-fluorophenyl in base form or addition salt with an acid.