Recent progress of fluorescent probes for the detection of alkaline phosphatase (ALP): A review

Abstract Alkaline phosphatase (ALP) that is a crucial biomarker for the diagnosis of hepatobiliary and skeletal diseases is widely distributed in human bone, liver, intestine, placenta and other tissues. The abnormal level of ALP is also associated with some other diseases, such as extrahepatic biliary obstruction, intrahepatic space occupying lesions, rickets and cancers. In recent years, to understand the roles of ALP in these diseases, various fluorescent probes have been developed to detect ALP activity in serum, and image ALP in cells and tumor tissues. In this paper, we put the emphasis on the properties of these fluorescent probes and provided two tables for more intuitive understanding of their performance in ALP detection. We hope this review can provide some help and enlightenment for the future works.