Association of Transforming Growth Factor-Beta1 rs1982073 Polymorphism with Susceptibility to Acute Renal Rejection: a Systematic Review and Meta-Analysis.

PURPOSE: The association of rs1982073 (codon 10) polymorphism at Transforming Growth Factor- ?1 (TGF-?1) gene with acute renal rejection (ARR) has been reported by several studies. However, the results were controversial. To derive a more precise estimation of this association, a meta-analysis was performed. METHODS: The eligible literatures were identified through PubMed, Scopus, Web of Science, EMBASE, SciELO, WanFang, and CNKI databases up to July 01, 2019. The pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to calculate the strength of the association. RESULTS: A total of 23 case-control studies with 795 ARR cases and 1,562 non-AR controls were selected. Pooled data revealed that there was no significant association between TGF-Beta1 codon 10 polymorphism and an increased risk of ARR in the overall population (C vs. T: OR=0.908, 95% CI 0.750-1.099, p=0.322; CT vs. TT: OR=1.074, 95% CI 0.869-1.328, p=0.507; CC vs.TT: OR=0.509, 95% CI=0.738-1.253, p=0.770; CC+CT vs. TT: OR = 0.917, 95% CI 0.756-1.112, p = 0.376, and CC vs. CT+TT: OR=0.995, 95% CI 0.809-1.223, p=0.959). Moreover, stratified analysis revealed no significant association between the TGF-?1 rs1982073 polymorphism and ARR risk by ethnicity and cases type (recipient and donor). CONCLUSIONS: The current meta-analysis demonstrated that the TGF-?1 rs1982073 polymorphism was not significantly associated with increased risk of ARR. However, studies with a larger number of subjects among different ethnic groups are needed to further validate the results.