Advances in diagnosis and treatment of double-hit lymphoma

Double-hit lymphoma (DHL) is a B cell lymphoma with unique biological characteristics and high invasiveness. DHL lacks specificity in histomorphology. At present, its diagnosis still relies on fluorescence in situ hybridization (FISH) to detect rearrangement of MYC gene, BCL-2 and BCL-6 gene.DHL patients are generally treated with conventional chemotherapy, new drug therapy, and bone marrow transplantation. The overall prognosises of patients with DHL wasere all poor. In addition, the efficacy of new targeted drugs or new drugs combined with traditional drugs in the treatment of DHL remains to be confirmed. In this article, the current research of diagnosis, treatment, prognosis and research progress of new drugs on DHL are summarized. Key words: Lymphoma; Diagnosis; Genes, myc; Genes, bcl-2; Prognosis; Double-hit