Correlation between the adiponectin-leptin ratio and parameters of insulin resistance in patients with type 2 diabetes

Abstract We studied the correlation between the adiponectin-leptin (A/L) ratio and parameters of insulin resistance in 220 Japanese patients with type 2 diabetes (138 men and 82 women). Body mass index (BMI), triglycerides (TGs), HDL cholesterol (HDL), and preheparin serum lipoprotein lipase (LPL mass) were examined as laboratory parameters of the insulin resistance. The correlations between these laboratory parameters and adiponectin, leptin, or A/L ratio were studied. Adiponectin levels correlated significantly with BMI ( r = −0.298, P = .0003), TGs ( r = −0.221, P = .0092), HDL ( r = 0.31, P = .0002), and LPL mass ( r = 0.26, P = .0021) in men, and with TGs ( r = −0.29, P = .0093), HDL ( r = 0.239, P = .0338), and LPL mass ( r = 0.499, P r = 0.31, P = .0002) in men, and with BMI ( r = 0.71, P r = 0.26, P = .0201) in women. Adiponectin and leptin levels tended to correlate with these parameters in an opposite manner. On the other hand, A/L ratio significantly correlated with BMI ( r = −0.4, P r = −0.199, P = .0192), HDL ( r = 0.235, P = .0054), and LPL mass ( r = 0.244, P = .0390) in men, and with BMI ( r = −0.482, P r = −0.402, P = .0002), HDL ( r = 0.358, P = .0011), and LPL mass ( r = 0.487, P