Epigenome-wide association studies without the need for cell-type composition

James Zou,Christoph Lippert,David Heckerman,Martin J. Aryee,Jennifer Listgarten

Epigenome-wide association studies without the need for cell-type composition

2014

James Zou
Christoph Lippert
David Heckerman
Martin J. Aryee
Jennifer Listgarten

A statistical approach using a linear mixed model and principal-component analysis discovers phenotype-specific changes in epigenomes without requiring information on cell type composition.

Keywords:

Genetic association
Cell type
Mixed model
Biology
Bioinformatics
Epigenome
methylation analysis
Genome-wide association study
genome informatics
cell type composition
Epigenomics
Linear model

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