Comparative enzyme inhibition study of 1-deazapurines

A series of nitrogen heterocycles including the derivatives of 1-deazapurines, were studied for miscellaneous enzyme inhibition activities in search of the potent enzyme inhibitor. The hyperactive enzymes like carbonic anhydrase-II, phosphodiesterase-I, xanthine oxidase, α-glucosidase, and β-glucuronidase were selected for the study. The compounds 1, 2, 3, 6, 8, 11–13 and 15–17, showed significant and selective activities against different enzymes. The compounds 11 and 12 were found the most potent against carbonic anhydrase-II, α-glucosidase and β-glucuronidase in comparison to their standard compounds. These selective inhibitors can be used as lead compounds for development of drugs against various diseases associated with these enzymes.