Association of ADAM12 gene polymorphisms with knee osteoarthritis susceptibility

// Kewei Ren 1 , Yuan Ruan 2 , Jilei Tang 3 , Xuefeng Jiang 1 , Huiqing Sun 1 , Luming Nong 4 , Yanqing Gu 5 and Yuanyuan Mi 6 1 Department of Orthopedics, The Affiliated Jiangyin Hospital of Southeast University Medical School, Jiangyin 214400, China 2 Department of Minimally Invasive Spine Center, Renji Orthopedics Hospital, Shantou 515065, China 3 Department of Orthopedics, Qidong People’s Hospital, Nantong 226200, China 4 Department of Orthopedics, Changzhou No. 2 People’s Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China 5 Department of Orthopedics, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China 6 Department of Urology, Third Affiliated Hospital of Nantong University, Wuxi 214000, China Correspondence to: Luming Nong, email: nonglumingjy@sina.com Yanqing Gu, email: guyanqingjy@sina.com Yuanyuan Mi, email: miniao1984@163.com Keywords: a disintegrin and metalloprotease 12, knee osteoarthritis, polymorphism, risk, meta-analysis Received: April 25, 2017     Accepted: July 29, 2017     Published: September 08, 2017 ABSTRACT Previous studies that evaluated the association between a disintegrin and metalloprotease 12 ( ADAM12 ) gene polymorphisms and knee osteoarthritis (KOA) have given controversial and indefinite results. Therefore, we performed a meta-analysis to confirm this correlation. We searched the PubMed, Embase, and SinoMed databases for all papers published up to April 11, 2017. Overall, five different studies, totaling 2,353 cases and 3,668 controls, were retrieved on the basis of the search criteria for KOA susceptibility related to four polymorphisms (rs3740199, rs1278279, rs1871054, and rs1044122) in the ADAM12 gene. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of this association. Publication bias was assessed using Egger’s and Begg’s tests. The rs3740199 G/C polymorphism was found to be associated with increased KOA risk in men (e.g., CG versus GG: OR = 1.44, 95% CI = 1.02–2.04, P = 0.040), but not in the overall analysis and in analyses of other subgroups. Significantly increased associations were also found for the rs1871054 polymorphism (e.g., C versus T allele: OR = 1.85, 95% CI = 1.49–2.30, P < 0.001). However, there were no associations for the rs1278279 and rs1044122 polymorphisms. Furthermore, no obvious evidence of publication bias was detected. Our study indicated that the rs1871054 polymorphism of ADAM12 was significantly associated with increased KOA risk.