Parasitological, clinical and haematological response of children with Plasmodium falciparum to 4-aminoquinolines and to pyrimethamine-sulfadoxine with quinine in Western Kenya

Children with Plasmodium falciparum infections in Westem Province, Kenya, were studied in 1987 for their parasitological, clinical and haematological respose to chloroquine, to amodiaquine and to pyrimethamine-sulfadoxine plus quinine. Ninety-eight children under 5 years of age were treated in 1 of 2 hospitals. Of the 56 patients treated with chloroquine base 25 mg/kg, 91% had resistant infections, with 36% havingno significant decrease in parasitaemia (RIII resistance); however, 69% responded clinically within a week