Impact of Sleep Disorders on Depression and Patient-Perceived Health-Related Quality of Life in Multiple Sclerosis

Abstract Given that sleep disorders may have a detrimental impact on HRQOL, assessing for sleep disturbance among patients with MS is important because there are well-supported, efficacious treatment options for both insomnia and obstructive sleep apnea. Background: Sleep disorders in multiple sclerosis (MS) are associated with both reduced health-related quality of life (HRQOL) and depression. However, research investigating and comparing how the two most common sleep disorders—insomnia and obstructive sleep apnea—impact both depression and HRQOL in MS is limited. The goal of this study is to examine the impact of diagnosed sleep disorders on patient reported: (1) HRQOL and (2) depressive symptoms among patients with MS. Methods: Retrospective chart review of 531 patients with MS; 287 (54%) of whom also had a comorbid sleep disorder (either insomnia or obstructive sleep apnea; OSA) while the remaining 244 (46%) participants did not have a diagnosed sleep disorder. Results: Neither (1) average ratings of ...