Meta-ananlysis of comparative study on Ziprasidon injectio in the treatment of schizophrenia during acutephase

Objective To study the difference of efficacy and side e ffect of ziprasidon injection and haloperidol injectio in the treatment of schizophrenia during acutephase. Methods 6 comparative studies of ziprasidon injection and haloperidol injectio in the treatment of schizophrenia during acutephase were analyzed by meta-ananlysis. Results The significant difference in change of symptom afte and r before treatment by duloxetine was found, d=2.14, 95% CI(1.90,2.39),χ2=17.07,P0.01.Comparison between ziprasidon injection and haloperidol injectio at 24 hours treatment and at the end of each trial showed that y合并=-0.10,95% CI(-0.77, 0.57,χ2=0.29,P0.05;y合并=-0.17,95% CI(-0.71, 0.37),χ2=0.62,P0.05, which revealed that there was no singnificant difference between ziprasidon injection and haloperidol injectio with respect to the clinical efficacy,with significantly less adverse effects compared with haloperidol injectio. Conclusion Ziprasidon injection has a similar clinical effecacy with haloperidol injectio,less adverse effects.