Brain-Computer Interface Based on Magnetic Particle Imaging For Diagnostic and Neurological Rehabilitation in Multiple Sclerosis

Applications of brain-computer interface (BCI) based on data of magnetic particle image (MPI) scanning of biological effector bound in-vivo magnetic nanoparticles (MNs) can be a desirable method of providing noninvasive diagnostic and neurological rehabilitative solutions for patients having various neurological dysfunctions such as, Multiple Sclerosis (MS). MNs may be dispensed to a patient for noninvasive localized monitoring of neurodegenerative disease by measuring changes in action potential along a neuron or by measuring levels of inflammation by determining concentrations of cellular debris at a particular point of interest in the brain such as at impaired nerve fibers of a neuron. The MNs may be configured for bidirectional communication with an electronic device in electrical communication with a MPI machine. Further, these MNs may be configured for drug delivery to a predetermined location associated with brain inflammation or to actuate the pharmacokinetic expulsion of toxic cellular debris.