A randomized, controlled, multicentre clinical trial of post‐extraction alveolar ridge preservation

Aim To compare the effectiveness of two-ridge preservation treatments. Materials and Methods 40 subjects with extraction sockets exhibiting substantial buccal dehiscences were enrolled and randomized across 10 standardized centers. Treatments were demineralized allograft plus reconstituted and cross-linked collagen membrane (DFDBA+RECXC) or deproteinized bovine bone mineral with collagen plus native, bilayer collagen membrane (DBBMC+NBCM). Socket dimensions were recorded at baseline and 6-months. Wound closure and soft tissue inflammation were followed post-operatively, and biopsies were retrieved for histomorphometric analysis at 6-months. Results Primary endpoint: at 6-months extraction socket horizontal measures were significantly greater for DBBMC+NBCM (average 1.76 mm greater, p= 0.0256). Secondary and Exploratory endpoints: (1) lingual and buccal vertical bone changes were not significantly different between the two treatment modalities, (2) histomorphometric % new bone and % new bone+graft were not significantly different, but significantly more graft remnants remained for DBBMC; (3) at 1-month incision line gaps were significantly greater and more incision lines remained open for DFDBA+RECXC; (4) higher inflammation at 1-week tended to correlate with lower ridge preservation results; and (5) deeper socket morphologies with thinner bony walls correlated with better ridge preservation. 37 of 40 sites had sufficient ridge dimension for implant placement at 6-months; the remainder were DFDBA+RECXC sites. Conclusion DBBMC+NBCM provided better soft tissue healing and ridge preservation for implant placement. Deeper extraction sockets with higher and more intact bony walls responded more favorably to ridge preservation therapy. Further investigation of implant integration and long-term survival is warranted. clinicaltrials. gov identifier NCT02330523. This article is protected by copyright. All rights reserved.