SUMOylation of the GTPase Rac1 is required for optimal cell migration

Sonia Castillo-Lluva,Michael H. Tatham,Richard C. Jones,Ellis Jaffray,Ricky D. Edmondson,Ronald T. Hay,Angeliki Malliri

SUMOylation of the GTPase Rac1 is required for optimal cell migration

2010

Sonia Castillo-Lluva
Michael H. Tatham
Richard C. Jones
Ellis Jaffray
Ricky D. Edmondson
Ronald T. Hay
Angeliki Malliri

The SUMO E3 ligase PIAS3 is shown to promote Rac1 SUMOylation. This modification stimulates Rac1 activity and regulates its ability to drive lamellipodium formation.

Keywords:

Ubiquitin ligase
Cell biology
Molecular biology
GTPase
Ubiquitin
RAC1
Cell migration
Kinase
Signal transduction
SUMO protein
Biology
Nuclear localization sequence

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