Optimizing planning CT using past CT images for prostate cancer volumetric modulated arc therapy

Abstract This study aimed to evaluate a new method to optimize planning computed tomography (CT) using three-dimensional (3D) displacement error between the planning and diagnosed past CT scans. Thirty-two patients undergoing volumetric modulated arc therapy for prostate cancer were evaluated for a 3D displacement error between bone- and prostate-matching spatial coordinates using multiple acquisition planning CT (MPCT) scans. Each MPCT image and a past CT image were used to perform rigid image registration (RIR) and deformable image registration (DIR), and the 3D displacement error was calculated. Correlations of the 3D displacement error in each MPCT scan and between the MPCT and past CT were evaluated based on RIR and DIR, respectively. The 3D displacement error in the MPCT images exhibited moderate correlation with the 3D displacement error between MPCT and past CT for both RIR (adjusted r2 = 0.495) and DIR (adjusted r2 = 0.398). In the correlation analysis between MPCT and past CT, image pairs with 3D displacement errors ≥ 6 mm were significantly different from those with errors