1242 Granisetron (G)-dexamethasone (D) combination for multiple day cisplatin (C)

34 patients (pts) being given polychemotherapy schedules including C at the dose of 20 mg/m 2 for 5 days entered an antiemetic protocol with G and D at the doses of 3 mg and 8 mg respectively, both administered i.v. before cisplatin. Pts received 108 cycles (range 1–6). A complete antiemetic response has been observed in 14/34 (41.1%) pts and 80/108 (70.4%) cycles; a major response has been observed in 12/34 (35.3%) pts and 16/108 (14.8%)cycles; a minor response in 2/34 (5.8%) pts and 5/108 (4.6%) cycles; a failure in 6/34 (17.6%) pts and 7/108 (6.4%) cycles. Nausea was absent in 424/540 days of therapy, rare in 72/540 and frequent in 44/540 days. Cefalea was in 16/34 pts and stipsis in 8/34 pts. G-D is able to determinate a high rate of antiemetic control in the special set of multiple day C treated pts.