Stereotactic body radiation therapy (SBRT) combined with chemotherapy for locally advanced pancreatic adenocarcinoma.

361 Background: The role of conventionally fractionated radiation therapy in the management of locally advanced pancreatic cancer (LAPC) is controversial. One concern about concurrent chemoradiation relates to the timing of systemic chemotherapy. In contrast to conventional radiation therapy, SBRT delivers high doses in a shorter duration resulting in minimal disruption in chemotherapy. Here we report our results of patients treated with SBRT and chemotherapy for LAPC. Methods: Twenty-seven patients treated with SBRT for LAPC at our institution from January 1, 2008 to December 31, 2012 were included in this retrospective analysis. Treatment was delivered in 5 fractions of 5 or 6 Gy per fraction in one week. The PTV included the pancreatic mass plus adjacent vasculature in most patients. The majority of patients received concurrent chemotherapy. Median time from diagnosis to SBRT was 1.9 months. Toxicities were scored using the CTCAE v.3. Survival was calculated using the Kaplan-Meier method. Results: The ...