APP Ser675 phosphorylation affects α-secretase processing resulting in decreased secretion of the neuroprotective ectodomain sAPPα

Niina Koistinen,Preeti Menon,Kerstin Iverfeldt,Anna-Lena Ström

APP Ser675 phosphorylation affects α-secretase processing resulting in decreased secretion of the neuroprotective ectodomain sAPPα

2017

Niina Koistinen
Preeti Menon
Kerstin Iverfeldt
Anna-Lena Ström

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by abnormal deposition of the amyloid-β (Aβ) peptide. Aβ is produced after amyloidogenic (β-secretase) processing of the trans ...

Keywords:

Secretion
Amyloid precursor protein secretase
Phosphorylation
Neuroprotection
Peptide
Cell biology
Ectodomain
Chemistry
α secretase

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