076 Inflammatory complications of CGRP monoclonal antibodies

Background CGRP monoclonal antibodies (mAb) are an effective new preventative treatment for episodic and chronic migraine, with a favourable adverse event profile. In addition to its role in mediating migraine attacks, CGRP is widely expressed throughout the body and in general has an anti-inflammatory/immunoregulatory role. Thus, inhibitory CGRP may potentiate a pro-inflammatory state. Methods/Results We present a case series of eight patients with new or worsened inflammatory pathology in close temporal association with the start of CGRP mAb therapy. Conclusions This case series provides novel insights on the potential molecular mechanisms and side-effect profile of CGRP inhibition and warrants vigilance in clinical practice.