Validation and cross-cultural adaptation of the questionnaire ThyPRO in thyroid patients in Serbia.
2015
Backgraund/Aim. The Thyroid Specific Patient Reported Outcome Measure
(ThyPRO) questionnaire is self-administered and intended to measure quality
of life of thyroid patients. The aim of this study was to investigate the
validity and reliability of the translated new, ThyPRO questionnaire in
Serbian patients with thyroid disease. Methods. The translation process
followed an internationally accepted methodology. The questionnaire was
validated in 100 consecutive thyroid patients hospitalized in a tertiary
level hospital, between April and August 2012. Internal reliabilities of
ThyPRO scales were assesessed using Cronbach’s α coefficient. Association
between age, gender, education, marital and employment status, place of
living, diagnosis, current treatment, hormonal status and patient quality of
life were determined using Pearson’s (r) and Spearman’s (q) correlation
coefficients. Results. Internal consistency and reliability for ThyPRO scales
were satisfactory. Cronbach’s α coefficients of 13 multi-item scales of the
ThyPRO were > 0.83 (range 0.83-0.95). The scores, obtained by this
questionnaire, correlated significantly with patients gender, employment
status, diagnosis, current treatment and place of living. A highly
significant inverse relationship was found between scores and hormonal status
as well as between scores and disease duration. Patients’ age, marital status
and thyroid-stimulating hormone level did not influence any scale score.
Conclusion. The ThyPRO may be useful in measuring health-related quality of
life in patients with thyroid disease in Serbia. [Projekat Ministarstva nauke
Republike Srbije, br. 175 042]
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