The clinic value of peripheral blood AFP mRNA and ALB mRNA in diagnosis and monitoring metastasis of hepatocellular carcinoma

Objective To explore the clinical value of peripheral blood albumin gene and alpha-fetoprotein gene in early diagnosis and differential diagnosis ofhepatocellular carcinoma(HCC).Methods Two gene fragments were amplified by nested reverse transcription polymerase chain reaction(RT-PCR)with the samples from patients.Results The positive tales of peripheral blood gene fragments from patients with HCC were 53.7％in AFP and 59.7％in Alb.respectively.The former Wag signifieantly higher than that in liver cirrhosis(LC),chronic hepatitis(CH),acute hepatitis(AH)and extrahepatic tumor(ET).The latter Wag also significantly higher than that in LC,CH and ET(P

Keywords:

• Gene
• Reverse transcription polymerase chain reaction
• Albumin
• Differential diagnosis
• Hepatocellular carcinoma
• Cirrhosis
• Cancer research
• Carcinoma
• Medicine
• Metastasis

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