Substitution Monotherapy With Levetiracetam vs Older Antiepileptic Drugs

Tahir Hakami,Marian Todaro,Slavé Petrovski,Lachlan MacGregor,Dennis Velakoulis,Meng Tan,Zelko Matkovic,Alexandra Gorelik,Danny Liew,Raju Yerra

Substitution Monotherapy With Levetiracetam vs Older Antiepileptic Drugs

2012

Tahir Hakami
Marian Todaro
Slavé Petrovski
Lachlan MacGregor
Dennis Velakoulis
Meng Tan
Zelko Matkovic
Alexandra Gorelik
Danny Liew
Raju Yerra

Randomizedcomparativetrial.Participantswithpartialepilepsywhohadfailedmonotherapywithphenytoinsodium, carbamazepine, or valproate sodium were ran-domizedtosubstitutionmonotherapywithlevetiracetamoradifferentolderAED.Assessmentswereperformedatbaseline,3months,and12monthsusingquestionnairesmeasuringneuropsychiatric,QOL,seizurecontrol,AEDadverse effects, and neurocognitive outcomes.

Keywords:

Levetiracetam
Carbamazepine
Neurocognitive
Valproate Sodium
Medicine
Pharmacology

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