Research advance in the risk of offspring with assisted reproductive technology and strategies to improve the safety of maternity and progeny

With the increase in the incidence of infertility and the development of assisted reproductive technology (ART), the proportion of people born through ART in the total population of the society is increasing. It causes wide attention whether or not the non-physiological interventions involved in ART would threaten the safety of the offspring. Although most studies suggest that ART is safety, there are some worrying findings. This article reviews the results of perinatal outcomes, birth defects, endocrine and metabolic diseases, physical and cognitive abnormalities and childhood tumors, and considers how to improve the safety of maternity and progeny. Key words: Reproductive techniques, assisted; Congenital abnormalities; Endocrine system diseases; Cognition disorders