Pharmacological activation of liver X receptor during cigarette smoke exposure adversely affects alveolar macrophages and pulmonary surfactant homeostasis

Éric Jubinville,Joanie Routhier,Michaël Maranda-Robitaille,Marie Pineault,Nadia Milad,Maude Talbot,Marie-Josée Beaulieu,Sophie Aubin,Marie-Ève Paré,Mathieu Laplante,Mathieu C. Morissette

Pharmacological activation of liver X receptor during cigarette smoke exposure adversely affects alveolar macrophages and pulmonary surfactant homeostasis

2019

Éric Jubinville
Joanie Routhier
Michaël Maranda-Robitaille
Marie Pineault
Nadia Milad
Maude Talbot
Marie-Josée Beaulieu
Sophie Aubin
Marie-Ève Paré
Mathieu Laplante
Mathieu C. Morissette

Smoking alters pulmonary reverse lipid transport and leads to intracellular lipid accumulation in alveolar macrophages. We investigated whether stimulating reverse lipid transport with an agonist o...

Keywords:

Pulmonary surfactant
Inflammation
Liver X receptor
Intracellular
Agonist
Biochemistry
Diabetes mellitus
Biology
Homeostasis
Lipid Transport
Endocrinology
Internal medicine

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