High Dose Intravenous Human IgG in the Treatment of Idiopathic Membranous Nephropathy: Preliminary Report of a Multicentric Trial

Twenty six adult patients were treated with high dose intravenous immuneglobulin (Endobulin-Immuno) for idiopathic membranous nephropathy and nephrotic syndrome.Pulse doses of 0.4 g/Kg b. wt. for 3 consecutive days were given and repeated twice after 3 weeks. Afterwards, one pulse dose every 3 weeks has been administered for a 12 months period. At the end of the study, 11 patients had a complete remission (daily proteinuria <0.2 g), 8 patients had a partial remission (daily proteinuria ≤3.5 g. mean 2.27±0.6 g).On the whole, 19 responders (73%) and 7 non-responders (27%).