KRAS: The Art of Understanding a Complex Gene

Abstract Kirsten rat sarcoma viral oncogene (K-ras) is one of the most frequent mutations of non-small cell lung cancer (NSCLC), specifically lung adenocarcinoma. Historically K-ras has been a mutation of great resilience and complexity. This shifted the focus of therapies to several of its related signaling pathways and cytokines. However, due to a greater understanding of the intricacies behind this mutation a greater arsenal of therapies has become available to us in the form of direct K-ras therapy. With this cumulative knowledge, we hope to bring an end to this irrepressible mutation in the future.