Progress in the study of long non-coding RNA in tongue squamous cell carcinoma

Abstract Tongue squamous cell carcinoma (TSCC) is the most common oral squamous cell carcinoma, which is highly malignant, giving rise to the lymph node metastasis or distant organ metastasis, thus the overall survival rate of the patient's decreases. Researches on the molecular mechanism of the biological characteristics of TSCC and exploration of targeted therapies have become the frontier in the study of TSCC. As a type of non-coding RNA, long non-coding RNA plays an essential role in the occurrence and development of tumors. In recent years, more and more reports on the Long non-coding RNA have been focusing on tongue cancer. Long non-coding RNA affects proliferation, invasion, and migration of TSCC cells through a variety of methods and molecular mechanisms. With reference to recent reports, this paper provides an overview of the molecular mechanisms of various Long non-coding RNAs and functions in TSCC.