Disseminated complex vascular malformations

Diffuse complex vascular malformations are sporadic or hereditary. They usually concern one type of vessel: capillary, venous or arterial (with AV fistula). They involve skin, mucosal membranes and internal organs. They lead to a rich and heterogeneous symptomatology, depending on the lesional localizations. Five out of them are described: cutis marmorata, Rendu Osler disease, Bean syndrome, Maffucci syndrome, and Proteus syndrome.