Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission

Ralda Nehme,Emanuela Zuccaro,Sulagna Ghosh,Chenchen Li,John Lawrence Sherwood,Olli P.H. Pietiläinen,Lindy E. Barrett,Francesco Limone,Kathleen A. Worringer,Sravya Kommineni,Ying Zang,Davide Cacchiarelli,Alexander Meissner,Rolf Adolfsson,Stephen J. Haggarty,Jon M. Madison,Matthias Müller,Paola Arlotta,Zhanyan Fu,Kevin Eggan,Guoping Feng

Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission

2018

Transcription factor programming of pluripotent stem cells (PSCs) has emerged as an approach to generate human neurons for disease modeling. However, programming schemes produce a variety of cell t ...

Keywords:

NMDA receptor
Biology
Excitatory postsynaptic potential
Neuroscience
Neurotransmission

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