EFFECTS OF NEFAZODONE ON DELAYED TYPE HYPERSENSITIVITY (DTH) RESPONSE IN STRESSED MICE

Experiments were conducted to evaluate the effects of nefazodone (10 mg/kg/day) on the delayed type hypersensitivity (DTH) response of mice exposed to an auditory stressor. Our results show that the DTH response to sheep red blood cells (SRBC) was inhibited by the stress and this difference was greater when stress was administered before SRBC sensitization. Treatment with nefazodone was found to partially reverse the adverse effect of stress on this immune parameter.