The relationship between childhood trauma and depression

The occurrence of depression is related to many factors, and the current research mainly focus on biological aspects such as biochemistry, neuroendocrine and immune, and genetic factors.However, as an important psychological factor, the relationship between childhood trauma and depression has not been paid enough attention.Therefore, it is important to discuss and summarize the relationship between them.Many literatures have shown that childhood trauma can significantly increase the prevalence of depression, which has a great impact on the clinical characteristics and treatment of patients with depression.The mechanism may be related to the changes in cognitive and psychological patterns caused by trauma.In addition, childhood trauma can affect the epigenetics and brain structure of patients with depression.Based on the above findings, the public should pay attention to the mental health problems in childhood, minimize or avoid childhood trauma, so as to reduce the occurrence of depression. Key words: Major depressive disorder; Childhood trauma; Clinical features