Study on the Relationship of G20210A Prothrombin mutation with Unexplained recurrent Spontaneous Abortion

Thrombophilia is a multigenic disorder caused by inherited and acquired defects. Pregnancy loss is reported to be more common in women with inherited and acquired thrombophilias. Recurrent fetal loss is a frequent health problem, with three or more and two or more affecting up to 5% of women in the reproductive age. Several specific thrombophilias found to be associated with spontaneous abortions are factor V Leiden, methylenetetrahydrofolate reductase, and prothrombin mutations. The aim of this study was to investigate the relationship between recurrent miscarriages and prothrombin (factor II) blood coagulation factor mutations. We conducted study including a clinically well-defined group of 70 patients with spontaneous abortions to test the association between prothrombin (Factor II) blood coagulation factor mutations and recurrent spontaneous abortions in Iranian population. In the present case control study, blood coagulation factor mutations has been investigated in 65 patients with spontaneous abortions and 80 healthy subjects by using Multiplex PCR and reverse dot blot methods. Then, the data were analyzed by SPSS software. The results of this study did not show considerable association between prothrombin (factor II) blood coagulation factor