Resuscitation with hypertonic saline dextran improves cardiac function in vivo and ex vivo after burn injury in sheep

ABSTRACTIn a 24 h, double-blind, prospective trial, we tested the hypothesis that two 4 mL/kg doses of hypertonic saline dextran (HSD; 7.5% NaCl/6% dextran 70) given in addition to isotonic fluid treatment would produce both immediate and sustained benefit for the heart after large burn injury. 12 i