Impact of food on the pharmacokinetics and electrocardiographic effects of sustained release verapamil in normal subjects

Abstract To evaluate the impact of food on the pharmacokinetics and electrocardiographic effects of sustained release (SR) verapamil tablets, 9 healthy men each received 3 single doses of verapamil in a randomized, crossover manner: 10 mg of intravenous verapamil, 240 mg SR verapamil on an empty stomach, and 240 mg SR verapamil with a standardized meal. PR intervals and racemic verapamil serum concentrations were measured serially over 30 hours after administration. The time to peak concentration was longer (7.5 ± 3.0 vs 4.4 ± 2.3 hours), resulting in a lower peak verapamil serum concentration (118 ± 43 vs 175 ± 50 ng/ml) when SR verapamil was administered with food (p