The Reproducibility of an Abbreviated Fat Tolerance Test in Young Healthy Participants: A Pilot Study (P12-029-19)

Objectives Triglyceride (TG) responses following a high-fat meal are more strongly associated with cardiovascular disease (CVD) risk compared with fasting TG levels. The current protocol for assessing post-meal TG is a burdensome process, involving serial blood draws for up to 8 hours. We have developed an abbreviated fat tolerance test (AFTT) that yields highly similar TG results relative to the standard protocol. The objective of this study is to determine whether the AFTT is reproducible and how it compares to the reproducibility of the oral glucose tolerance test (OGTT), a metabolic challenge already in clinical use.