Hémoglobinurie nocturne paroxystique : diagnostic à l'aide d'un anticorps monoclonal dirigé contre la glycoprotéine Decay accelerating factor
1993
The laboratory diagnosis of paroxysmal nocturnal haemoglobinuria (also called Marchiafava-Micheli disease) is based on the sensitivity of the patient's red cells to complement-induced lysis. In view of the clonal expression of the disease, haemolysis tests are difficult to interpret when the abnormal red cell population is small. The sensitivity of abnormal red cells to haemolysis is due to the absence of proteins attached to the cell membrane by a phosphatidyl-inositol link, which intervene in the regulation of the complementinduced lysis mechanism
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