Histopathologic changes during mesenteric ischaemia and reperfusion
2004
The basic electrical rhythm (BER) of the intestine is known to decrease during mesenteric ischaemia. Some studies have reported the relationship between the BER and the pathologic changes that occur in the bowel during vascular injury. However, these changes have not been completely elucidated. This study describes the histopathologic pattern when the rabbit small intestine was subjected to ischaemia of varying time lengths (30 – 150 minutes) and subsequent reperfusion for six hours. Intestinal biopsies were taken at baseline, at the end of ischaemia, and at hourly intervals during reperfusion. Microscopic examination of the biopsies revealed evidence of progressive infarction of the mucosa during ischaemia. There was an acute worsening of the pathology during reperfusion, the severity being greater when reperfusion was preceded by longer periods of ischaemia. These changes were statistically significant. The observed pattern in this study shows clearly that reperfusion injury is reflected in the histopathologic response and that this is worse in severity than the response to ischaemia. Studies of longer duration should further clarify the picture during recovery in ischaemia/reperfusion injuries of the bowel. Keywords: Mesenteric, Ischaemia, Reperfusion, Pathology. Resume
Le rythme electrique normal (Basic Electrical Rhythm, BER) de l'intestin diminue pendant la deficience de sang. Quelques etudes ont releve une relation entre le rythme electrique normal (BER) et les changements pathologiques qui se produisent dans la cavite intestinale lors de l'injurie vasculaire. Neanmoins ces changements n'ont pas ete completement elucides. Cette etude decrit le type histopathologique quand l'intestin grele du cobaye etait soumis a la deficience pendant un temps varie (30 – 150mn) et la reperfusion subsequent de six heures.
Les biopsies intestinales etaient portees a la baseline a la baseline a la fin de la deficience et a intervals d'une heure durant la reperfusion. L'examen microscopique des biopsies revele l'evidence d'infarction progressive de muchose durant la deficience. Il y avait une detoriation accrue de la pathologie durant la reperfusion la severite etait plus grande que quand la reperfusion etait precedee par une plus longue periode de deficience. Ces changement etaient significants statistiquement. Le model observe dans cette montre clairement que l'injurie de reperfusion est reflectee dans la reponse histopathologique et que ca s'empire en severite que dans la reponse a la deficience. Les etudes d'une duree plus longue peuvent clarifier l'image durant le retablissement de l'injurie de la deficience reperfusion de la cavite intestinale. West African Journal of Medicine Vol.22(1) 2003: 59-62
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