Increase of CXCL14 and CXCR7 expression in human squamous lung cancers compared to its adjacent normal lung tissues.

e22099 Background: Lung squamous cell carcinoma (SQCC) is the second-largest histological subtype of non-small-cell lung cancer, but relatively less biomarkers are available compared to adenocarcinoma. Recently, chemokines and their receptors have been suggested to play important roles in the initiation or progression of cancers. In this study we examined the expression of chemokine and their receptor in human lung squamous cancer compared with adjacent normal tissue. Methods: Tumor and its adjacent normal lung specimens were collected from fresh frozen samples of 10 patients with primary lung SQCC subjected to curative surgical resection from November 2011 to October 2012 at our institute. To detect chemokines and their receptors mRNA, human chemokines and receptors PCR array (Qiagen) was used. We employed a tissue microarray to examine CXCL14 and CXCR7 expression by immunohistochemical staining in 35 consecutive lung SQCC specimens and their adjacent normal lung tissues collected from November 2011 to M...