ЭКСПРЕССИЯ ГЕНОВ ЦИРКАДНОГО РИТМА CLOCK, BMAL1 И PER1 В КЛЕТКАХ БУККАЛЬНОГО ЭПИТЕЛИЯ У БОЛЬНЫХ ЭССЕНЦИАЛЬНОЙ АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИЕЙ

The analysis of differences in the expression rates of the main circadian genes  CLOCK, BMAL1,  and  PER1  in human oral mucosa cells between patients with essential hypertension (EH) and healthy individuals was carried out for the first time. The expression levels of the genes were calculated at 9:00 a.m., 1:00 p.m., and 5:00 p.m. Patients with EH exhibited lower expression levels of the  CLOCK gene at 1:00 p.m. and 5:00 p.m. as compared with control group. The expression levels of the  BMAL1  gene were significantly lower at 9:00 a.m. and 1:00 p.m. in comparison with healthy individuals. Patients with EH exhibited lower expression levels of the  PER1  gene at all time points as compared to control group. The signifi cant positive corre i ation between expression levels of  CLOCK  and  PER1, BMAL1  and  PER1  genes was shown in control group and donors with EH at all time points using Spearman rank correlation analysis.