Considering the Impact of Type 2 Diabetes Mellitus—Biological Mechanisms in COVID-19 Pathology

Diabetes is one of the most prevalent comorbidities among patients with COVID-19, and specific minorities in the USA are being disproportionately affected The biologic mechanism underpinning this association is still unknown;however, there are known causal relationships between hyperglycemia and dysregulated immunity in the diabetic population in sepsis and acute respiratory distress syndrome Diabetes may impact the pathogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), possibly via glycosylation of a key receptor, angiotensin-converting enzyme 2 It is imperative that we further understand this link in order to attenuate the critical illness caused by COVID-19 among diabetics