Preparation and Characterization of Magnetic Nanospheres for in Vivo Application

New biodegradable magnetic nanospheres were synthesized for the application in the magnetic field assisted radionuclide therapy. For this purpose, superparamagnetic iron oxide cores were coated with several hydrophilic polymers, such as dextran, starch, chitosan, ficoll, polyethylene imine and polyvinylpyrrolidone. The different surface properties of these magnetic polymer nanospheres were demonstrated by a significant variation of the electrophoretic mobility of the particles in dependence on the pH-value.